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Toward resilient cloud warehousing via a blockchain-enabled auction approach

《工程管理前沿（英文）》页码 20-38 doi: 10.1007/s42524-022-0224-2

摘要： Cloud warehousing service (CWS) has emerged as a promising third-party logistics service paradigm driven by the widespread use of e-commerce. The current CWS billing method is typically based on a fixed rate in a coarse-grained manner. This method cannot reflect the true service value under the fluctuating e-commerce logistics demand and is not conducive to CWS resilience management. Accordingly, a floating mechanism can be considered to introduce more flexible billing. A CWS provider lacks sufficient credibility to implement floating mechanisms because it has vested interests in terms of fictitious demand. To address this concern, this report proposes a blockchain-enabled floating billing management system as an overall solution for CWS providers to enhance the security, credibility, and transparency of CWS. A one-sided Vickrey–Clarke–Groves (O-VCG) auction mechanism model is designed as the underlying floating billing mechanism to reflect the real-time market value of fine-grained CWS resources. A blockchain-based floating billing prototype system is built as an experimental environment. Our results show that the O-VCG mechanism can effectively reflect the real-time market value of CWSs and increase the revenue of CWS providers. When the supply of CWS providers remains unchanged, allocation efficiency increases when demand increases. By analyzing the performance of the O-VCG auction and comparing it with that of the fixed-rate billing model, the proposed mechanism has more advantages. Moreover, our work provides novel managerial insights for CWS market stakeholders in terms of practical applications.

关键词： resilient cloud warehousing blockchain technology floating billing management system auction mechanism third-party logistics

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效率不确定下企业物流管理模式的柔性选择研究

张红波,罗一新

《中国工程科学》 2008年第10卷第9期页码 88-91

摘要：

分析了物流管理模式及我国物流管理现状，通过建立模型，采用实物期权分析方法，得到了物流服务效率不确定条件下企业从自营物流管理模式转向采用第三方物流管理模式的门槛值。分析结果表明，自营物流服务的效率、企业原有资产的损失及交易成本的大小、物流服务效率提高速度的快慢与物流服务效率的不确定程度，会对企业物流管理模式的选择产生重要影响。

关键词：企业物流管理模式实物期权自营物流第三方物流柔性选择

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POLICIES AND REGULATIONS FOR PROMOTING MANURE MANAGEMENT FOR SUSTAINABLE LIVESTOCK PRODUCTION IN CHINA: A REVIEW

Sha WEI, Zhiping ZHU, Jing ZHAO, David R. CHADWICK, Hongmin DONG

《农业科学与工程前沿（英文）》 2021年第8卷第1期页码 45-57 doi: 10.15302/J-FASE-2020369

摘要： Livestock numbers in China have more than tripled between 1980 and 2017. The increase in the number of intensive livestock production systems has created the challenges of decoupled crop and livestock systems, low utilization of manures in croplands, and subsequent environmental pollution. Correspondingly, the government has enacted a series of policies and regulations to increase the sustainability of livestock production. This paper reviews the objectives of these policies and regulations and their impacts on manure management. Since 2017 there have been two policy guides to speed up the appropriate use of manures, three action plans for increasing manure recycling, and one technical guide to calculate nutrient balances. Requirements of manure pollution control and recycling for improved environmental performance of livestock production systems were included in three revised environmental laws. Most recent survey data indicate that the utilization of livestock manures was 70% in 2017, including that used as fertilizer and/or for production of energy. The targets for manure utilization are 75% in 2020 and 90% in 2035. To achieve these targets and promote ‘green livestock production’, additional changes are needed including the use of third-party enterprises that facilitate manure exchange between farms and a more integrated manure nutrient management approach.

关键词： integrated crop and livestock production manure utilization policy recommendations sustainability third-party service contractors

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Integrating operations research into green logistics: A review

《工程管理前沿（英文）》页码 517-533 doi: 10.1007/s42524-023-0265-1

摘要： Logistical activities have a significant global environmental impact, necessitating the adoption of green logistics practices to mitigate environmental effects. The COVID-19 pandemic has further emphasized the urgency to address the environmental crisis. Operations research provides a means to balance environmental concerns and costs, thereby enhancing the management of logistical activities. This paper presents a comprehensive review of studies integrating operations research into green logistics. A systematic search was conducted in the Web of Science Core Collection database, covering papers published until June 3, 2023. Six keywords (green logistics OR sustainable logistics OR cleaner logistics OR green transportation OR sustainable transportation OR cleaner transportation) were used to identify relevant papers. The reviewed studies were categorized into five main research directions: Green waste logistics, the impact of costs on green logistics, the green routing problem, green transport network design, and emerging challenges in green logistics. The review concludes by outlining suggestions for further research that combines green logistics and operations research, with particular emphasis on investigating the long-term effects of the pandemic on this field.

关键词： green logistics operations research environment literature review

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Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors

null

《医学前沿（英文）》 2016年第10卷第4期页码 383-388 doi: 10.1007/s11684-016-0488-1

摘要：

The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the first line of therapy for advanced non-small cell lung cancer (NSCLC). Acquired mutations in EGFR account for one of the major mechanisms of resistance to the TKIs. Three generations of EGFR TKIs have been used in clinical applications. AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positive advanced NSCLC patients. However, resistance to AZD9291 arises after 9–13 months of therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. To overcome the acquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitor that overcomes T790M- and C797S-mediated resistance. This review summarizes recent investigations on the mechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor.

关键词： EGFR tyrosine kinase inhibitor AZD9291 EAI045

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Operations management of smart logistics: A literature review and future research

Bo FENG,Qiwen YE

《工程管理前沿（英文）》 2021年第8卷第3期页码 344-355 doi: 10.1007/s42524-021-0156-2

摘要： The global collaboration and integration of online and offline channels have brought new challenges to the logistics industry. Thus, smart logistics has become a promising solution for handling the increasing complexity and volume of logistics operations. Technologies, such as the Internet of Things, information communication technology, and artificial intelligence, enable more efficient functions into logistics operations. However, they also change the narrative of logistics management. Scholars in the areas of engineering, logistics, transportation, and management are attracted by this revolution. Operations management research on smart logistics mainly concerns the application of underlying technologies, business logic, operation framework, related management system, and optimization problems under specific scenarios. To explore these studies, the related literature has been systematically reviewed in this work. On the basis of the research gaps and the needs of industrial practices, future research directions in this field are also proposed.

关键词： smart logistics operations management optimization Internet of Things

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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

《医学前沿（英文）》 2022年第16卷第5期页码 701-713 doi: 10.1007/s11684-022-0951-0

摘要： A significant clinical challenge in lung cancer treatment is management of the inevitable acquired resistance to third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), such as osimertinib, which have shown remarkable success in the treatment of advanced NSCLC with EGFR activating mutations, in order to achieve maximal response duration or treatment remission. Apoptosis is a major type of programmed cell death tightly associated with cancer development and treatment. Evasion of apoptosis is considered a key hallmark of cancer and acquisition of apoptosis resistance is accordingly a key mechanism of drug acquired resistance in cancer therapy. It has been clearly shown that effective induction of apoptosis is a key mechanism for third generation EGFR-TKIs, particularly osimertinib, to exert their therapeutic efficacies and the development of resistance to apoptosis is tightly associated with the emergence of acquired resistance. Hence, restoration of cell sensitivity to undergo apoptosis using various means promises an effective strategy for the management of acquired resistance to third generation EGFR-TKIs.

关键词： acquired resistance EGFR inhibitor apoptosis lung cancer

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Underground logistics systems: Development overview and new prospects in China

《工程管理前沿（英文）》 2023年第10卷第2期页码 354-359 doi: 10.1007/s42524-023-0252-6

摘要： Underground logistics systems: Development overview and new prospects in China

关键词： China

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中国物流业及物流技术刍议

罗一新,薛伟

《中国工程科学》 2004年第6卷第6期页码 79-84

摘要：

从我国物流业的现状出发，肯定了我国物流业在发展过程中取得的成就，并从物流规划、物流标准、物流技术、物流人才等几个方面分析了我国物流业存在的主要问题，提出了解决这些问题的建议，以期推动我国物流业的进一步发展。

关键词：物流发展问题措施

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Multi-stage emergency medicine logistics system optimization based on survival probability

Ke WANG, Yixin LIANG, Lindu ZHAO

《工程管理前沿（英文）》 2017年第4卷第2期页码 221-228 doi: 10.15302/J-FEM-2017020

摘要： Using sudden cardiac deaths as an example and maximizing survival rate as the goal, this paper studies the influence of multi-stage medical logistics system optimization on the survival rate of sudden illness. A distribution model of survival is built, drone and ambulance arrival probability over time are discussed, a formula is proposed for maximum possible survival rate based on the probability of emergency medical logistics reaching the patient, and the results are analyzed using empirical data fitting distribution and numerical experiments performed with the model. The model is discussed as a reference point for management decision making by changing model parameters. Results show that compared to using current ambulance vehicles, ambulance drones delivering medical equipment for first aid on-site in emergencies can significantly increase survival rate, and the effect of collaborative multi-stage logistics optimization is better than that of any single stage logistics response optimization. Simulation results show that the medical rescue logistics service radius, speed, loading capacity and performance of ambulance drones impact the probability of survival, and there is an optimal service radius depending on the shape of probability distribution, which provides new information for management decisions.

关键词： emergency medicine logistics ambulance drone survival probability critical illness

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An Intelligent Logistics Management Model in Prefabricated Construction

Chong-guang Feng,Hao Hu,Feng Xu,Jian Yang

《工程管理前沿（英文）》 2015年第2卷第2期页码 178-181 doi: 10.15302/J-FEM-2015038

摘要： In recent years, with the increasingly complex fabricated construction environment and increasingly challenging logistics management requirements, this paper proposes a model of intelligent logistics management based on radio frequency identification and building information modeling, which enables monitoring full life cycle of building components and improving construction efficiency through real-time uploading and tracking components and materials logistics information. The empirical model was typically used in the construction of a major theme park with good results achieved.

关键词： logistics management intelligent construction BIM RFID fabricated construction major theme park

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Erratum to: Past review, current progress, and challenges ahead on the cocktail party problem

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

《信息与电子工程前沿（英文）》 2018年第19卷第4期 doi: 10.1631/FITEE.17e0814

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Dynamic analysis of composite beam subjected to harmonic moving load based on the third-order shear deformation

Mohammad Javad REZVANIL, Mohammad Hossein KARGARNOVIN, Davood YOUNESIAN

《机械工程前沿（英文）》 2011年第6卷第4期页码 409-418 doi: 10.1007/s11465-011-0245-8

摘要：

The response of an infinite Timoshenko beam subjected to a harmonic moving load based on the third-order shear deformation theory (TSDT) is studied. The beam is made of laminated composite, and located on a Pasternak viscoelastic foundation. By using the principle of total minimum potential energy, the governing partial differential equations of motion are obtained. The solution is directed to compute the deflection and bending moment distribution along the length of the beam. Also, the effects of two types of composite materials, stiffness and shear layer viscosity coefficients of foundation, velocity and frequency of the moving load over the beam response are studied. In order to demonstrate the accuracy of the present method, the results TSDT are compared with the previously obtained results based on first-order shear deformation theory, with which good agreements are observed.

关键词： timoshenko composite beam pasternak viscoelastic foundation third-order shear deformation theory (TSDT) harmonic moving load

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

《医学前沿（英文）》 2022年第16卷第1期页码 93-101 doi: 10.1007/s11684-021-0914-x

摘要： Inducing durable and effective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via vaccination is essential to combat the current pandemic of coronavirus disease 2019 (COVID-19). It has been noticed that the strength of anti-COVID-19 vaccination-induced immunity fades over time, which calls for an additional vaccination regime, as known as booster immunization, to restore immunity among previously vaccinated populations. Here we report a pilot open-label trial of a third dose of BBIBP-CorV, an inactivated SARS-CoV-2 vaccine (Vero cell), on 136 participants aged between 18 to 63 years. Safety and immunogenicity in terms of neutralizing antibody titers and cytokine/chemokine responses were analyzed as the main endpoint until day 28. While systemic reactogenicity was either absent or mild, SARS-CoV-2-specific neutralizing antibody titers rapidly arose in all participants within 4 weeks, surpassing the peak antibody titers elicited by the initial two-dose immunization regime. Broad increases of cellular immunity-associated cytokines and chemokines were also detected in the majority of participants after the third vaccination. Furthermore, in an exploratory study, a newly developed recombinant protein vaccine, NVSI-06-08 (CHO Cells), was found to be safe and even more effective than BBIBP-CorV in eliciting humoral immune responses in BBIBP-CorV-primed individuals. Together, these results indicate that a third immunization schedule with either homologous or heterologous vaccine showed favorable safety profiles and restored potent SARS-CoV-2-specific immunity, providing support for further trials of booster vaccination in larger populations.

关键词： COVID-19 SARS-CoV-2 vaccine immunization booster immunization